Nonfluoride caries-preventive agents: new guidelines.

UNLABELLED Nonfluoride caries-prevention agents have been developed and promoted to the dental profession in the recent past. The oral healthcare professional is encouraged to use evidence-based information when making clinical decisions. Recently, a systematic review was completed by a panel of experts convened by the American Dental Association Council on Scientific Affairs and recommendations were developed to address efficacy of nonfluoride agents in reducing the incidence of caries and arresting or reversing the progression of caries. The panel found that all nonfluoride agents should be used as adjuncts, following initial use of primary caries prevention strategies (fluoride, sealants, anticaries diet). This paper discusses the levels of certainty for evidence statements and clinical applications of these recommendations. CLINICAL SIGNIFICANCE The panel concluded that certain nonfluoride agents may provide some benefits as adjunctive therapies in children and adults at higher risk of developing caries.